Applied Sciences, Vol. 15, Pages 7876: Upgrading Renewable Phenols to Functional Benzyl Chlorides and Formamides: Versatile Building Blocks for the Chemical Industry

Applied Sciences doi: 10.3390/app15147876

Authors:
Nicola Porcelli
Biagio Anderlini
Alberto Ughetti
Mattia Giuliana
Matteo Fiocchi
Fabrizio Roncaglia

A reliable synthetic method based on the already known Blanc–Quelet methodology has been developed for upgrading bio-based phenols into valuable electrophilic mono-, di-, and trifunctional benzyl chlorides. These compounds show significant potential as building blocks for polymer production and the synthesis of specialty chemicals. As an example of their applicability, their direct interaction with formamide has been evaluated, obtaining an effective transformation towards the corresponding N-formylamides. These compounds represent versatile synthetic precursors to a variety of functionalized targets.

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Nicola Porcelli www.mdpi.com