Applied Sciences, Vol. 15, Pages 8165: Simulation Study on the Effects of Environment and Structure on Bone Tissue Scaffold Flow Properties

Applied Sciences doi: 10.3390/app15158165

Authors:
Yameng Xiao
Yunshen Zhang
Yun Guo

One of the hottest topics in current research is the creation of scaffolds for bone tissue restoration that are both biocompatible and tissue inducible. The aim of this work is to develop a numerical model to study the effects of temperature, velocity, and scaffold structure on flow and biomechanical properties, as well as to optimize design parameters to improve tissue engineering outcomes. The results show that the fluid transport properties of cylindrical unit cell architectures are superior. For effective mass transfer, pore diameters > 4 mm and porosity > 60% are ideal design parameters. With important clinical and financial implications, these discoveries offer theoretical direction and economical methods for developing bone tissue engineering.

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