Biomedicines, Vol. 13, Pages 1929: Association of Intratumoral Microbiota Modulation with Prostate Cancer Progression: A Microbiome Analysis of Prostatic Tissue

Biomedicines doi: 10.3390/biomedicines13081929

Authors:
Jae Heon Kim
Hoonhee Seo
Sukyung Kim
Md Abdur Rahim
Sujin Jo
Indrajeet Barman
Hanieh Tajdozian
Faezeh Sarafraz
Md Sarower Hossen Shuvo
Ho-Yeon Song
Yun Seob Song

Background: The involvement of the intratumoral microbiome in prostate cancer progression is becoming increasingly acknowledged. This study analyzed the microbiome of prostate cancer tissues from patients with localized prostate cancer (LPC, stages 1–2) and advanced prostate cancer (APC, stages 3–4) to determine its association with cancer progression. Methods: Paraffin-embedded tissue samples obtained during radical prostatectomy underwent 16S rRNA amplicon-based profiling. Results: The profile of the bacterial communities in LPC and APC differed remarkably. While species diversity remained stable, species richness (as determined by the ACE analysis) was significantly lower in APC, correlating with a decrease in Enhydrobacter (which is more abundant in LPC) and an increase in Lautropia (enriched in APC). The role of Lautropia in the progression of cancer was confirmed by in vitro studies employing cell lines from prostate cancer. Conclusions: These findings demonstrate the potential of microbiome-targeted interventions in the management of prostate cancer.

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Jae Heon Kim www.mdpi.com