Biomolecules, Vol. 15, Pages 1373: Advances in Computational Drug Repurposing, Driver Genes, and Therapeutics in Lung Adenocarcinoma

Biomolecules doi: 10.3390/biom15101373

Authors:
Sajjad Nematzadeh
Arzu Karaul

This review catalogs candidate LUAD driver genes and their roles, recent discoveries, and therapeutic avenues. Beyond experimental repurposing, we evaluate modern computational methods and how they complement bench work. We conclude by appraising recent LUAD repurposing studies through a computational lens, emphasizing practical integration into translational research. Highlights: Overview of drug repurposing methods: We provide a list of six experimental and a brief taxonomy of eight computational drug repurposing method families. Recent insights into LUAD driver genes: We present a curated panel of LUAD drivers mapped to pathways, with alteration types, functions, and therapeutic implications. LUAD-focused computational repurposing studies: We provide a synthesis of recent LUAD studies presenting clear method families, highlighting exemplar pipelines, prioritized candidate drugs, and datasets.

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Sajjad Nematzadeh www.mdpi.com