Ceramics, Vol. 8, Pages 124: Enhanced Transdermal Delivery via Electrospun PMMA Fiber Mats Incorporating Ibuprofen-Intercalated Layered Double Hydroxides

Ceramics doi: 10.3390/ceramics8040124

Authors:
Van Thi Thanh Tran
Shusei Yamashita
Hideaki Sano
Osamu Nakagoe
Shuji Tanabe
Kai Kamada

This study reports the development of electrospun poly(methyl methacrylate) (PMMA) fiber mats incorporating ibuprofen (IBU)-intercalated layered double hydroxides (LDH) for enhanced transdermal drug delivery systems (TDDS). IBU, in its anionic form, was successfully intercalated into LDH, which possesses anion exchange capabilities, and subsequently embedded into PMMA fibers via electrospinning. In vitro drug release experiments demonstrated that UPMMA–LDH–IBU fibers exhibited significantly higher IBU release than PMMA–IBU controls. This enhancement was attributed to the improved hydrophilicity and water absorption imparted by the LDH, as confirmed by contact angle and water uptake measurements. Furthermore, artificial skin permeation tests revealed that the UPMMA–LDH–IBU fibers maintained comparable release rates to those observed during buffer immersion, indicating that the rate-limiting step was the diffusion of IBU within the fiber matrix rather than the interface with the skin or buffer. These findings highlight the critical role of LDH in modulating drug release behavior and suggest that UPMMA–LDH–IBU electrospun fiber mats offer a promising and efficient platform for advanced TDDS applications.

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