CIMB, Vol. 47, Pages 239: The Role of Injectable Platelet-Rich Fibrin in Orthopedics: Where Do We Stand?

Current Issues in Molecular Biology doi: 10.3390/cimb47040239

Authors:
Fábio Ramos Costa
Sergio Augusto Lopes de Souza
Rubens Andrade Martins
Bruno Ramos Costa
Luyddy Pires
Alex Pontes de Macedo
Napoliane Santos
Stephany Cares Huber
Gabriel Silva Santos
André Kruel
Márcia Santos
José Fábio Lana

Injectable Platelet-Rich Fibrin (i-PRF) has emerged as a promising tool in regenerative medicine, particularly in orthopedics, due to its unique biological properties and ease of preparation. i-PRF is an autologous platelet concentrate derived through a simple, anticoagulant-free centrifugation process, resulting in a liquid matrix enriched with fibrin, leukocytes, and growth factors. These components promote tissue regeneration, angiogenesis, and anti-inflammatory responses, making i-PRF suitable for bone and cartilage repair as well as drug delivery systems. This review discusses the history, biological mechanisms, and clinical applications of i-PRF in orthopedics, highlighting its potential advantages over traditional platelet-rich plasma (PRP). Furthermore, we address the challenges and limitations of i-PRF, including drug stability, release control, and bioactive interactions, underscoring the need for further research to optimize its therapeutic efficacy.

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Fábio Ramos Costa www.mdpi.com