Cosmetics, Vol. 12, Pages 272: Hydro Deluxe Skin Boosters and the Cutaneous Microbiome: A Narrative Review

Cosmetics doi: 10.3390/cosmetics12060272

Authors:
Carlos José Téllez-Castillo
Leticia Amselem Albuixech
Raquel Fernández de Castro Izalguez

Background/Objective: The skin microbiome plays a pivotal role in barrier function, immune regulation, and overall skin health. Age-related changes and environmental stressors disrupt microbial homeostasis, contributing to inflammaging and esthetic concerns. This narrative review aims to explore the potential interactions between the Hydro Deluxe Skin Booster and the cutaneous microbiome, with emphasis on barrier integrity, hydration, and molecular pathways relevant to skin aging. Methods: A literature search was performed in PubMed and Scopus up to September 2025. Keywords included skin microbiome, cutaneous dysbiosis, hyaluronic acid (HA), calcium hydroxyapatite (CaHA), amino acids, skin boosters, skin aging, barrier function, and inflammation. Eligible articles included in vitro ex vivo, and clinical studies addressing microbiome-related mechanisms in skin health and esthetic interventions. Results: The literature indicates that HA and skin boosters enhance hydration and reduce transepidermal water loss (TEWL), indirectly supporting microbial balance. Aging is associated with sebaceous decline, altered pH, reduced levels of commensals (Cutibacterium acnes, Staphylococcus epidermidis), and increased opportunists (Streptococcus, Staphylococcus aureus). Hydro Deluxe, a formulation combining HA, CaHA, and amino acids, may synergistically stabilize the cutaneous environment by restoring hydration, reducing inflammatory mediators, and promoting dermal remodeling. Current evidence, however, is largely limited to in vitro and ex vivo data. Conclusions: Hydro Deluxe appears to be a promising esthetic intervention with potential to support cutaneous microbial homeostasis and mitigate age-associated inflammatory changes. Further well-designed clinical trials are warranted to validate its microbiome-related effects and to clarify its role in evidence-based esthetic medicine.

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Carlos José Téllez-Castillo www.mdpi.com