COVID, Vol. 5, Pages 58: Detection of SARS-CoV-2 in Ascitic Fluid of Cirrhotic COVID-19 Patients: Case Series and Literature Review

COVID doi: 10.3390/covid5040058

Authors:
Grazia Caci
Andrea Marino
Edoardo Campanella
Ylenia Russotto
Cristina Micali
Natascia Laganà
Aldo Sitibondo
Roberto Filomia
Antonino Botindari
Serena Spampinato
Giuseppe Mancuso
Angelina Midiri
Giovanni Francesco Pellicanò
Giuseppe Nunnari
Emmanuele Venanzi Rullo

SARS-CoV-2 has been identified in multiple organs and fluids, including the liver and peritoneal fluid. Gastrointestinal symptoms, such as abdominal pain, diarrhea, nausea, and vomiting, can exacerbate COVID-19 outcomes by contributing to complications, like acid–base imbalances and cardiovascular dysfunction, particularly in patients with pre-existing conditions. We report three cases of COVID-19 cirrhotic patients with SARS-CoV-2 detected in their ascitic fluid and review the relevant literature on the virus’s presence and clinical significance in peritoneal fluid. These findings underscore diagnostic and prognostic challenges in managing COVID-19 in patients with chronic liver disease and highlight the need for further research to clarify viral dissemination mechanisms and optimize protective measures for healthcare workers during surgical procedures.

Source link

Grazia Caci www.mdpi.com