Entropy, Vol. 28, Pages 238: The Interplay Between Non-Instantaneous Dynamics of mRNA and Bounded Extrinsic Stochastic Perturbations for a Self-Enhancing Transcription Factor

Entropy doi: 10.3390/e28020238

Authors:
Lorenzo Cabriel
Giulio Caravagna
Sebastiano de Franciscis
Fabio Anselmi
Alberto D’Onofrio

In this work, we consider a simple bistable motif constituted by a self-enhancing Transcription Factor (TF) and its mRNA with non-instantaneous dynamics. In particular, we mainly numerically investigated the impact of bounded stochastic perturbations of Sine–Wiener type affecting the degradation rate/binding rate constant of the TF on the phase-like transitions of the system. We show that the intrinsic exponential delay in the TF positive feedback, due to the presence of a mRNA with slow dynamics, deeply affects the above-mentioned transitions for long but finite times. We also show that, in the case of more complex delays in the feedback and/or in the translation process, the impact of the extrinsic stochasticity is further amplified. We also briefly investigate the power-law behavior (PLB) of the averaged energy spectrum of the TF by showing that, in some cases, the PLB is simply due to the filtering nature of the motif. A similar analysis can also be applied to biological models having a qualitatively similar structure, such as the well-known Capasso and Paveri–Fontana model of cholera spreading.

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Lorenzo Cabriel www.mdpi.com