Gels, Vol. 12, Pages 153: Magnetic-Graphene-Oxide-Incorporated Alginate Hydrogel Beads as a Potential Controlled Drug Delivery System

Gels doi: 10.3390/gels12020153

Authors:
Somayeh Sadighian
Tabassom Mahmoudie
Abolfazl Kordloo
Mohammad Reza Heydari
Akram Khanmohammadi
Zahra Kaboli
Narges Forouzideh

The aim of this study was to synthesize alginate hydrogel beads using ionotropic gelation containing pH-sensitive magnetic reduced graphene oxide (MGO). MGO was prepared using a hydrothermal method and surrounded by alginate beads. FTIR, XRD, FESEM, TEM, VSM and TGA showed that the synthesized beads have a quasi-spherical structure, exhibit superparamagnetic behavior, and are thermally stable up to 350 °C. The model drug, quercetin, was loaded into these particles with an efficiency of 25.8%. These particles showed a pH-dependent release. HFF-2 and Caco-2 cells were used to investigate cytotoxicity. At a concentration of 140 μg/mL, more than 80% viability was observed in HFF-2 cells and anticancer effects were observed on Caco-2 cells with a decrease in viability of less than 50% at a concentration of 200 μg/mL. The obtained cell culture results indicate that the hydrogel beads are biocompatible and act as a drug delivery system.

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Somayeh Sadighian www.mdpi.com