IJMS, Vol. 26, Pages 5996: Association of Tissue Expression of LAG-3 and TIM-3 with Clinical Features in Ovarian Cancer

International Journal of Molecular Sciences doi: 10.3390/ijms26135996

Authors:
Dominika Borzyszkowska
Mateusz Kozłowski
Anna Golara
Katarzyna Piotrowska
Agnieszka Brodowska
Jacek Brodowski
Iwona Bojar
Agnieszka Kempinska-Podhorodecka
Aneta Cymbaluk-Płoska

One of the most prevalent types of cancer among women is ovarian cancer. The search for ovarian cancer markers is constantly ongoing. Evaluation of LAG-3 and TIM-3 protein expression in ovarian cancer tissue and its role in distinguishing the clinical signs stated were the objectives of this study. Methods: A total of 58 ovarian cancer patients were recruited for this study. The cohort was split into two groups: one for high-grade serous ovarian cancer (HGSOC) and another for ovarian cancer that was not HGSOC (non-HGSOC). LAG-3 and TIM-3 protein expression in ovarian cancer tissue samples was evaluated by immunohistochemistry. StatView 5.0 software (Carry, NC, USA) was used for all statistical analyses. Both LAG-3 and TIM-3 proteins mostly showed positive, moderately positive, or strongly positive expression. This study shows that LAG-3 could be a marker associated with BMI in the non-HGSOC group. TIM-3 may be a marker associated with age in a group of all ovarian cancers. LAG-3 expression is associated with TIM-3 expression in the total cohort and the HGSOC and non-HGSOC groups.

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