IJMS, Vol. 26, Pages 8708: Bridging Inflammation and Repair: The Promise of MFG-E8 in Ischemic Stroke Therapy

International Journal of Molecular Sciences doi: 10.3390/ijms26178708

Authors:
Ye-Jin Han
Hye-Jin Lee
Dong-Ho Geum
Jong-Hoon Kim
Dong-Hyuk Park

Ischemic stroke is a neurological disorder resulting from localized brain injury due to focal cerebral ischemia, typically caused by the blockage of one or, in some cases, a few cerebral arteries. This arterial obstruction leads to hypoxia and energy failure, culminating in primary brain damage. Although reperfusion is critical to salvage viable tissue, it often intensifies injury through oxidative stress, inflammation, and cell death—a phenomenon called ischemia–reperfusion (I/R) injury. Milk fat globule-EGF factor 8 (MFG-E8), a multifunctional glycoprotein secreted by stem and immune cells, is a key regulator of inflammation and tissue repair. By modulating microglial activation, attenuating proinflammatory cytokine releases, and preserving neuronal integrity, MFG-E8 mitigates ischemia–reperfusion injury and emerges as a novel therapeutic target for ischemic stroke.

Source link

Ye-Jin Han www.mdpi.com