J. Compos. Sci., Vol. 9, Pages 706: Antibacterial and Non-Toxic to Mammalian Cell Composite Material Based on Polymethyl-Methacrylate-like Resin Containing Grain-Shaped Copper Oxide Nanoparticles

Journal of Composites Science doi: 10.3390/jcs9120706

Authors:
Fatikh M. Yanbaev
Dmitriy N. Ignatenko
Anastasiia V. Shabalina
Ilya V. Baimler
Dmitry E. Burmistrov
Maxim E. Astashev
Vasily N. Lednev
Alena A. Nastulyavichus
Roman Yu. Pishchalnikov
Ruslan M. Sarimov
Alexander V. Simakin
Sergey V. Gudkov

Granular copper oxide nanoparticles (CopOx NPs), synthesized via laser ablation (100 nm, ζ-potential +30 mV), were introduced into photolithographic polymethyl methacrylate (PMMA) resin at concentrations of 0.001–0.1%. The resulting composite material enables the fabrication of high-resolution (up to 50 μm) parts with a high degree of surface quality after polishing using the MSLA method. CopOx NPs increased the degree of resin polymerization (decrease by almost 4× in unpolymerized components at 0.1% CopOx NPs) and induced the in situ formation of self-organized periodic structures visible under a modulation interference microscope. The composite samples exhibit pronounced oxidative activity: they intensify the generation of hydrogen peroxide and hydroxyl radicals and cause the oxidative modification of biomolecules (formation of 8-oxoguanine in DNA and long-lived reactive forms of proteins). A key property of the materials is their selective biological activity. While lacking cytotoxicity for human fibroblasts, they exhibit a strong antibacterial effect against E. coli, leading to cell death within 24 h. Thus, the developed composite photolithographic resin combines improved technological characteristics (high printing resolution, degree of polymerization) with functional properties (selective antibacterial activity) and holds promise for application in biomedicine, as well as in the food and agricultural industries.

Source link

Fatikh M. Yanbaev www.mdpi.com