JCM, Vol. 14, Pages 8548: Current Challenges of Managing Fibrosis Post Glaucoma Surgery and Future Perspectives

Journal of Clinical Medicine doi: 10.3390/jcm14238548

Authors:
Phey Feng Lo
Seok Ting Lim
Xiaomeng Wang
Tina T. Wong

The primary cause of post-operative failure following glaucoma filtration surgery is excessive bleb scarring. Traditional anti-fibrotics such as Mitomycin C (MMC) and 5-fluorouracil (5-FU) have greatly improved bleb survival but are not without their complications. Insights gained from traditional trabeculectomy studies can be directly applied to modern minimally invasive glaucoma surgery (MIGS) techniques. As surgical techniques continue to advance and overall safety improves, there is a growing need to explore other novel therapeutics that offer increased efficacy and favourable safety profiles. This review aims to provide insight into the pathophysiology of wound healing as well as discuss current and emerging strategies being developed to address wound healing post glaucoma filtration surgery.

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