Microbiology Research, Vol. 16, Pages 191: Prevalence and Factors Associated with Tuberculosis Among Healthcare Workers: A Systematic Review with Meta-Analysis

Microbiology Research doi: 10.3390/microbiolres16080191

Authors:
Alessandro Rolim Scholze
Paola Obreli Bersi
Mariane Cândido da Silva
Júlia Trevisan Martins
Emiliana Cristina Melo
Maria José Quina Galdino
Flávia Meneguetti Pieri
Felipe Mendes Delpino
Yan Mathias Alves
Thais Zamboni Berra
Oclaris Lopes Munhoz
Josilene Dália Alves
Mellina Yamamura
Ricardo Alexandre Arcêncio

Background: Healthcare workers are exposed to an unhealthy environment that increases the risk of developing tuberculosis. Objective: To analyze the prevalence and factors associated with tuberculosis among healthcare workers. Methods: A systematic review with meta-analysis was conducted using six databases. Methodological quality was assessed according to JBI recommendations. A random-effects meta-analysis was performed. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were followed for reporting. Results: Thirty-two articles were included in the evidence synthesis. The prevalence of tuberculosis among healthcare workers was found to be 15.92% [95% CI 8.49–27.88|I2 = 99% | p = 0]. Female sex was associated with 1.37 times higher odds of infection [95% CI 0.68–2.38, I2 = 80%, p = 0.01]. Advanced age increased the odds by 1.47 times [95% CI 1.33–4.62, I2 = 76%, p = 0.01]. Conclusions: Early diagnosis of tuberculosis in the workplace and the implementation of continuing education programs with preventive strategies are essential to control contamination and the spread of the disease: CRD42022320153.

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