Microorganisms, Vol. 13, Pages 1208: Impact of Psychopathology and Gut Microbiota on Disease Progression in Ulcerative Colitis: A Five-Year Follow-Up Study

Microorganisms doi: 10.3390/microorganisms13061208

Authors:
Franco Scaldaferri
Antonio Maria D’Onofrio
Elena Chiera
Adrian Gomez-Nguyen
Gaspare Filippo Ferrajoli
Federica Di Vincenzo
Valentina Petito
Lucrezia Laterza
Daniela Pugliese
Daniele Napolitano
Elisa Schiavoni
Giorgia Spagnolo
Daniele Ferrarese
Lorenza Putignani
Loris Riccardo Lopetuso
Giovanni Cammarota
Fabio Cominelli
Antonio Gasbarrini
Gabriele Sani
Giovanni Camardese

Psychological distress and gut dysbiosis play key roles in IBD. This study investigated whether specific psychopathological and gut microbiota features predict adverse outcomes in UC patients. This retrospective cohort study included 35 UC patients recruited in 2019. Baseline assessments involved clinical interviews, psychiatric evaluations, and stool sampling. In 2024, follow-up interviews and medical record reviews assessed disease progression, including biologic therapy failure, hospitalization, surgery, and diagnosis changes. Disease activity was measured via the Mayo score. Psychological testing included MMPI-2, STAI-Y2, GSES, CD-RISC, and TAS-20. Patients with biological therapy failure showed increased levels of Proteobacteria, Fusobacteria, Enterobacteriaceae, and Trabulsiella, while Firmicutes were less abundant. UC-related hospitalized patients had lower levels of Rikenellaceae, Ruminococcaceae, Faecalibacterium, Lachnospira, Methanobrevibacter, and Phascolarctobacterium compared to non-hospitalized patients. Hospitalized patients scored higher on the Sc clinical scale and the OBS and HEA content scales. Acidaminococcus and Bilophila were more abundant in patients who underwent surgery. PCA revealed differences between patients with and without biological failure. Logistic regression found that Fusobacteria were negatively correlated with the failure of three or more biologics, while Hy and Pd were positively correlated. Pa and Pt were negatively correlated with multifailure. Obsessiveness, health concerns, somatization, and reduced SCFA-producing bacteria may predict UC-related adverse outcomes.

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Franco Scaldaferri www.mdpi.com