Molecules, Vol. 31, Pages 86: Magnetic Microrobots for Drug Delivery: A Review of Fabrication Materials, Structure Designs and Drug Delivery Strategies

Molecules doi: 10.3390/molecules31010086

Authors:
Jin Shi
Yanfang Li
Dingran Dong
Junyang Li
Tao Wen
Yue Tang
Qi Zhang
Fei Pan
Liqi Yan
Duanpo Wu
Shaowei Jiang

Magnetic microrobots have emerged as a promising platform for drug delivery in recent years. By enabling remotely controlled motion and precise navigation under external magnetic fields, these systems offer new solutions to overcome the limitations of traditional drug delivery nanocarriers, such as inadequate tissue penetration and heterogeneous biodistribution. Over the past few years, significant advancements have been made in the structural design of magnetic microrobots, as well as in drug loading techniques and stimuli-responsive drug release mechanisms, thereby demonstrating distinct advantages in enhancing therapeutic efficacy and targeting precision. This review provides a comprehensive overview of magnetic drug delivery microrobots, which are categorised into biomimetic structural, bio-templated and advanced material-based types, and introduces their differences in propulsion efficiency and biocompatibility. Additionally, drug loading and release strategies are summarised, including physical adsorption, covalent coupling, encapsulation, and multistimuli-responsive mechanisms such as pH, enzyme activity and thermal triggers. Overall, these advancements highlight the significant potential of magnetic microrobots in targeted drug delivery and emphasise the key challenges in their clinical translation, such as biological safety, large-scale production and precise targeted navigation within complex biological environments.

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Jin Shi www.mdpi.com