Neurology International, Vol. 17, Pages 13: Optical Coherence Tomography in Huntington's Disease—A Potential Future Biomarker for Neurodegeneration?

Neurology International doi: 10.3390/neurolint17010013

Authors:
Clancy Cerejo
Nicolas De Cleene
Elias Mandler
Katarina Schwarzová
Samuel Labrecque
Philipp Mahlknecht
Florian Krismer
Atbin Djamshidian
Klaus Seppi
Beatrice Heim

Huntington's disease (HD) is a progressive neurodegenerative disorder for which, until now, only symptomatic treatment has been available. Lately, there have been multiple ongoing clinical trials targeting therapeutic agents for preventing disease onset or slowing disease progression in HD. These studies are in constant need of reliable biomarkers for neurodegeneration in HD. In recent years, retinal biomarkers have attracted significant attention in neurodegenerative disorders. Likewise, optical coherence tomography (OCT) is being evaluated as a potential biomarker in HD. In this article, we review the existing literature on OCT as a biomarker for neurodegeneration in HD.

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Clancy Cerejo www.mdpi.com