Neurology International, Vol. 17, Pages 87: The C/C Genotype of the C-1019G (rs6295) Polymorphism of the 5-HT1A Receptor Gene Is Associated with Lower Susceptibility to Depressive Symptoms in a Rural Population in Mexico
Neurology International doi: 10.3390/neurolint17060087
Authors:
Margarita Hernandez-Mixteco
Olga Lidia Valenzuela
Cecilia Luz Balderas-Vazquez
Paola Castillo-Juárez
Sandra Rivera-Gutiérrez
Rocío Liliana García-Reyes
Gilberto Cornejo-Estudillo
Ricardo Jiovanni Soria-Herrera
Moises León-Juárez
Addy Cecilia Helguera-Repetto
Daniel Valencia-Trujillo
Victoria Campos-Peña
Eliud Alfredo Garcia-Montalvo
Jorge Francisco Cerna-Cortés
Background: Depression is one of the most prevalent mental health disorders worldwide, affecting a significant proportion of the global population. Its etiology is complex and influenced by the interaction of environmental factors and genetic variations. In Mexico, it has been reported that 41.3% of the population exhibits depressive symptoms. Previous studies have suggested that susceptibility to depression may be associated with the C-1019G (rs6295) polymorphism in the serotonin 1A (5-HT1A) receptor gene. Objective: In this study, we aimed to evaluate the association between the C-1019G polymorphism and depressive symptoms in a rural Mexican population. Methods: Using polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP), we examined the effect of C-1019G on depression symptoms, as evaluated by the Beck Depression Inventory. Data were obtained from 83 volunteers; individuals with depressive symptoms and those with a healthy mood were compared. Results: The results showed that the homozygous C/C genotype was found significantly more frequently in the control group than in individuals with depressive symptoms, particularly among men, and is thus associated with a decreased risk of depressive symptomatology. Conclusions: The C/C genotype could protect against susceptibility to developing depressive symptoms in a rural population in Mexico.
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Margarita Hernandez-Mixteco www.mdpi.com
