Veterinary Sciences, Vol. 12, Pages 886: Genomic Characteristics of a Novel Recombinant Bluetongue Virus Serotype 1 in Yunnan, China

Veterinary Sciences doi: 10.3390/vetsci12090886

Authors:
Yunyi Chen
Shimei Luo
Nijing Lei
Zhenghao Ye
Xianping Ma
Shaoyu Yang
Huaijie Jia
Guangyu Qi
Guanghua Wang
Huashan Yi

Bluetongue virus belongs to the Reoviridae family, which causes morbidity in ruminants. Herein, we report the full-length genome sequence of a recombinant BTV strain of serotype 1 (YNDH/103/2013) isolated from sentinel cattle in Yunnan Province, China, in 2013. To identify and understand the characteristics of YNDH/103/2013, we screened closely related viruses using Simplot 3.5.1 software and conducted verification via phylogenetic analysis using MEGA 11.0.13 software. Phylogenetic analysis and segment examination showed that the YNDH/103/2013 strain likely originated from multiple recombination events involving prevalent strains such as Y863, NRT37/ABT/HSR, and YTS-4 in China and India. The genome of BTV-1/YNDH/103/2013 derives from at least three reassortments with these strains, showing recombination breakpoints mainly in segments 4, 6, 8, and 9. This study improves our understanding of the origin and spread of BTV-1 in China.

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Yunyi Chen www.mdpi.com